姓名：何生 性別：男 政治面貌：中共黨員學(xué)歷：研究生學(xué)位：博士職稱：主任醫(yī)師
博、碩導(dǎo)師：本崗位工作年數(shù)：15年
研究方向：干細(xì)胞與心臟組織工程,，影像人工智能
榮譽(yù)稱號：山西省青年三晉英才,，第七屆中國國際“互聯(lián)網(wǎng)+”大學(xué)生創(chuàng)新創(chuàng)業(yè)大賽金獎(jiǎng)獲得者
學(xué)術(shù)任職：山西省醫(yī)師協(xié)會放射醫(yī)師分會常務(wù)委員，中國干細(xì)胞產(chǎn)業(yè)聯(lián)盟常務(wù)理事
近五年承擔(dān)科研課題情況：
1,、國家自然科學(xué)基金青年項(xiàng)目,81900274,可注射Ppy-Chi- hBMSCs-CMs,類心肌組織通過抑制心室重構(gòu)促進(jìn)心電同步化修復(fù)大鼠心梗的實(shí)驗(yàn)研究, 2020.01-2022.12,，主持；
2,、博士后科學(xué)基金面上項(xiàng)目,2021M691991,導(dǎo)電水凝膠聚吡咯殼聚糖增強(qiáng)人子宮內(nèi)膜間充質(zhì)干細(xì)胞改善缺血性心臟病功能的機(jī)制研究,2021.06- 2023.06,，主持
3、省留學(xué)基金,，2024-44,hEMSCs-EVs通過抑制NLRP3活化改善SiO2誘導(dǎo)肺損傷機(jī)制研究,，2024.06-2027.06，主持
4,、山西省基礎(chǔ)研究計(jì)劃項(xiàng)目,，202303021221214，多功能導(dǎo)電水凝膠PPY-CHI/HEMSCS-EXOS通過緩釋EGF和電整合促進(jìn)MI后功能恢復(fù),，2024.01-2026.12,，10萬元，主持
5,、省醫(yī)學(xué)重點(diǎn)科研項(xiàng)目,，2023XM031，hEMSCs-EVs治療SiO2誘導(dǎo)肺損傷和纖維化有效性及機(jī)制研究,，2023.07-2025.12,主持,，
代表性論著及近五年的代表性論文（限10項(xiàng)以內(nèi)）：
1.Yan C*, Wang X*, Wang Q*, Li H, Song H, Zhou J, Peng Z, Yin W, Fan X, Yang K, Zhou B, Liang Y, Jiang Z, Shi Y, Zhang S#,He S#, Li RK#, Xie J#. A Novel Conductive Polypyrrole-Chitosan Hydrogel Containing Human Endometrial Mesenchymal Stem Cell-Derived Exosomes Facilitated Sustained Release for Cardiac Repair. Adv Healthc Mater. 2024:e2304207(IF=10).
2.He S, J Wu, SH Li, L Wang, Y Sun, J Xie, D Ramnath, RD Weisel, TM Yau, HW Sung，RK Li. The conductive function of biopolymer corrects myocardial scar conduction blockage and resynchronizes contraction to prevent heart failure. Biomaterials. 2020;258:120285 (SCI1區(qū)TOP期刊IF=14,，他引38次) .
3.Fan X,He S, Song H, Yin W, Zhang J, Peng Z, Yang K, Zhai X, Zhao L, Gong H, Ping Y, Jiao X, Zhang S, Yan C, Wang H, Li RK, Xie J. Human endometrium-derived stem cell improves cardiac function after myocardial ischemic injury by enhancing angiogenesis and myocardial metabolism. Stem Cell Res Ther. 2021 12(1):344（IF=7.5）.
4.Liang Y, Shuai Q, Zhang X, Jin S, Guo Y, Yu Z, Xu X, Ao R, Peng Z, Lv H,He S,Wang C, Song G, Liu Z, Zhao H, Feng Q, Du R, Zheng B, Chen Z, Xie J. Incorporation of Decidual Stromal Cells Derived Exosomes in Sodium Alginate Hydrogel as an Innovative Therapeutic Strategy for Advancing Endometrial Regeneration and Reinstating Fertility. Adv Healthc Mater. 2024 :e2303674(IF=10).
5.Zhou B, Wei Y, Chen L, Zhang A, Liang T, Low JH, Liu Z,He S,Guo Z, Xie J. Microplastics exposure disrupts nephrogenesis and induces renal toxicity in human iPSC-derived kidney organoids. Environ Pollut. 2024;360:124645（IF=7.6）.
6.Shuai Q, Liang Y, Xu X, Halbiyat Z, Wang X, Cheng J, Liu J, Huang T, Peng Z, Wang L,He S,Zhao H, Liu Z, Xu J, Xie J. Sodium alginate hydrogel integrated with type III collagen and mesenchymal stem cell to promote endometrium regeneration and fertility restoration. Int J Biol Macromol. 2023 ;253(Pt 6):127314（IF=7.7）.
7.王馨竹,王琦,郎麗敏,何生#.聚吡咯-殼聚糖導(dǎo)電復(fù)合水凝膠促進(jìn)缺血-再灌注損傷后心臟功能的恢復(fù)[J].中國組織工程研究,2024,28(15):2315-2322.
8.王琦,王馨竹,姜增譽(yù),周景莉,何生#.可注射導(dǎo)電水凝膠聚吡咯-殼聚糖對慢性心肌梗死后心臟功能長期改善[J].實(shí)用醫(yī)學(xué)雜志,2023,39(13):1606-1613.
9.楊曉芳,張智星,王軍,梁敏茜,李卓君,黃忠江,陳文青,李健丁,姜增譽(yù)#,何生#.基于MRI的影像組學(xué)對PSA“灰區(qū)”且PI-RADS 3分及以上前列腺癌的診斷價(jià)值研究[J].臨床放射學(xué)雜志,2023,42(06):953-959.
教學(xué)科研
