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姓名：張麗 性別：女政治面貌：農(nóng)工黨黨員

學(xué)歷：研究生學(xué)位：博士職稱： 副教授

博、碩導(dǎo)師：碩士生導(dǎo)師 本崗位工作年數(shù)：5年

研究方向：再生醫(yī)學(xué)與表觀遺傳學(xué)

榮譽(yù)稱號(hào)：無

學(xué)術(shù)任職：山西醫(yī)科大學(xué)第一醫(yī)院干（體）細(xì)胞臨床研究學(xué)術(shù)委員會(huì)秘書,，山西省抗癌協(xié)會(huì)腫瘤樣本整合研究專業(yè)委員會(huì)委員等

近五年承擔(dān)科研課題情況：

1,、國家自然科學(xué)基金（青年項(xiàng)目），項(xiàng)目名稱：m6A修飾FNDC5在葉酸無應(yīng)答致神經(jīng)管畸形發(fā)生的作用及機(jī)制研究,，項(xiàng)目編號(hào)：82201319

2,、山西省科學(xué)技術(shù)廳（自由探索類青年基金），項(xiàng)目名稱：S-腺苷甲硫氨酸調(diào)控m6A修飾致神經(jīng)管畸形發(fā)生的機(jī)制研究,，項(xiàng)目編號(hào)：20210302124291

3,、山西醫(yī)科大學(xué)“百億工程”校級(jí)基金,，項(xiàng)目名稱：核黃素靶向FGF1在維甲酸介導(dǎo)的神經(jīng)管畸形的機(jī)制研究，項(xiàng)目編號(hào)：BYJL06

4,、山西省教育廳（高等學(xué)校一般性教學(xué)改革創(chuàng)新項(xiàng)目）,，項(xiàng)目名稱：研究生教學(xué)質(zhì)量管理數(shù)字化、信息化建設(shè)研究與實(shí)踐,，項(xiàng)目編號(hào)：2024JG086

5,、山西省教育廳（高等學(xué)校一般性教學(xué)改革創(chuàng)新項(xiàng)目），項(xiàng)目名稱：基于學(xué)習(xí)通平臺(tái)的線上多維動(dòng)畫與臨床化教學(xué)在生物化學(xué)教學(xué)中的應(yīng)用與探索,，項(xiàng)目編號(hào)：J20230448

6,、山西省衛(wèi)生健康委員會(huì)（一般項(xiàng)目），項(xiàng)目名稱：M6A RNA甲基化調(diào)控Wnt/β-catenin信號(hào)通路參與神經(jīng)管畸形的機(jī)制研究,，項(xiàng)目編號(hào)：2020090

7,、山西省教育廳（科技創(chuàng)新項(xiàng)目），項(xiàng)目名稱：METTL3介導(dǎo)的m6A修飾通過調(diào)控Wnt/β-catenin通路致神經(jīng)管畸形發(fā)生的機(jī)制研究,，項(xiàng)目編號(hào)：2021L181

8,、山西省衛(wèi)生健康委員會(huì)（實(shí)驗(yàn)室專項(xiàng)），項(xiàng)目名稱：PD-1/PD-L1信號(hào)通路在肝癌肝移植免疫應(yīng)答中的作用機(jī)制研究,，項(xiàng)目編號(hào)：2022142

代表性論著及近五年的代表性論文（限10項(xiàng)以內(nèi)）：

1,、Li Zhang^#*，Xiaona Zhang^#,，Yurong Liu^#,，Kaixin Wei^#，Huijing Ma,，Li Xia,，Rui Cao，Yuqing Sun,，Ronghua Zheng,，Xiuwei Wang*，Bingmei Chang*. Ethionine‐induced S‐adenosylmethionine deficiency suppressed H3K27me3 and cell differentiation during neural tube development in mice. J Cell Physiol. 2025 Jan;240(1):e31452.

2,、Li Zhang#, Dandan Li#, Yurong Liu, Xiaona Zhang, Kaixin Wei, Xiaorong Zhao, Huijing Ma, Bo Niu, Rui Cao*, Xiuwei Wang*. Cycloleucine induces neural tube defects by reducing Pax3 expression and impairing the balance of proliferation and apoptosis in early neurulation. Neurochemistry International.2024.105861. Epub 2024 Sep 20.

3,、Wenhao Shao#, Huaxing Ding#, Yan Wang, Zhiyong Shi, Hezhao Zhang, Fanxiu Meng, Qingyao Chang, Haojiang Duan, Kairui Lu,Li Zhang*,Jun Xu*.Key genes and immune pathways in T-cell mediated rejection postliver transplantation identified via integrated RNA-seq and machine learning.Scientific Reports 2024 Oct 16;14(1):24315.

4、Rui Cao, Yurong Liu, KaixinWei, Ning , Yuxiang , RuifangAo, Weiwei Pan, XiangWang, XiuweiWang*,Li Zhang*& Jun Xie*. Genes related to neural tube defects and glioblastoma.Scientific Reports 2025 Jan 30;15(1):3777.

5,、Xiuwei Wang, Kaixin Wei, Min Wang**,Li Zhang*. Identification of potential key ferroptosis and autophagy-related genes in myelomeningocele through bioinformatics analysis. Heliyon 2024 Apr 30;10(8):e29654.

6,、Haojiang Duan, Qingyao Chang, Huaxing Ding, Wenhao Shao, Yan Wang, Kairui Lu,Li Zhang*, Jun Xu*. GBP1 promotes acute rejection after liver transplantation by inducing Kupffer cells pyroptosis. Biochim Biophys Acta Mol Basis Dis. 2024 Dec 26:167644.

7、Yuxuan Zhang,，Qingjuan Li, Yuhu Niu, Kaixin Wei, Xiuwei Wang, Bo Niu,，Li Zhang*. Research progress on aging mechanism and drugs and the role of stem cells in anti-aging process. Experimental Gerontology. 2023 Aug;179.doi: 10.1016/j.exger.2023.112248.

8、Li Zhang, Rui Cao, Dandan Li, Yuqing Sun, Juan Zhang, Xiuwei Wang, Ajab Khan, Zhizhen Liu, Bo Niu*, Jun Xu* and Jun Xie*. Ethionine-mediated reduction of S-adenosylmethionine is responsible for the neural tube defects in the developing mouse embryo-mediated m6A modification and is involved in neural tube defects via modulating Wnt/β-catenin signaling pathway. Epigenetics & Chromatin. 2021 Dec 4;14(1):52.doi: 10.1186/s13072-021-00426-3.

9,、Zhang L, Dong Y, Wang W, Zhao T, Huang T, Khan A, Wang L, Liu Z, Xie J and Niu B. Ethionine Suppresses Mitochondria Autophagy and Induces Apoptosis via Activation of Reactive Oxygen Species in Neural Tube Defects. Front Neurol. 2020 Apr 7;11:242.

10,、Li Zhang, Dandan Li, Juan Zhang, Ping Yan, Ajab Khan, Xueqin Liu, Lei Wang, Zhizhen Liu, Jianbing Mu, Jun Xu, Bo Niu*, Jun Xie*. Excessive apoptosis and ROS induced by ethionine affects neural cells viability and differentiation[J]. Acta Biochimica et Biophysica Sinica 2020 Oct 19;52(10).